Epidemiology, etiology, and prevention of esophageal squamous cell carcinoma in China

He Liang, Jin-Hu Fan, You-Lin Qiao


Esophageal cancer is one of the most fatal diseases worldwide mainly because of its rapid progression and poor prognosis.Although the incidence of esophageal adenocarcinoma has markedly risen in North America and Europe in the past severaldecades, esophageal squamous cell carcinoma is still the predominant subtype of esophageal cancer, especially in China. Itaccounts for more than 90% of all esophageal squamous cell carcinoma cases in China. Geographical differentiation is one of themost distinctive characteristics of esophageal cancer. The progression, risk factors, and prognosis of these two subtypes ofesophageal cancer differ. This study reviews the epidemiology, etiology, and prevention of esophageal squamous cell carcinoma inChina, thereby providing systematic references for policy-makers who will decide on issues of esophageal cancer prevention andcontrol.


Epidemiology; etiology; prevention; esophageal squamous cell carcinoma; review

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