Univariate and multivariate analysis of post-transplant HCC overall survival
| Variable | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Donor age | 1.138 (0.958–1.352) | 0.142 | ||
| > 50 | ||||
| Donor sex | 1.145 (0.905–1.451) | 0.259 | ||
| Male | ||||
| Recipient sex | 1.376 (1.003–1.883) | 0.048 | 1.381 (1.006–1.895) | 0.046 |
| Male | ||||
| Donor BMI | 1.075 (0.901–1.284) | 0.424 | ||
| ≤ 23.9 | ||||
| ABO blood incompatibility | 1.918 (1.106–3.327) | 0.020 | 1.544 (0.889–2.683) | 0.123 |
| MELD score | 1.062 (0.888–1.269) | 0.512 | ||
| > 20 | ||||
| HBV (+) | 1.040 (0.816–1.326) | 0.749 | ||
| Child-Pugh A | 0.966 (0.866–1.076) | 0.529 | ||
| Largest tumor size | 2.591 (2.175–3.086) | < 0.001 | 1.627 (1.288–2.055) | < 0.001 |
| > 5 cm | ||||
| Cold ischemia time | 1.008 (0.822–1.237) | 0.939 | ||
| > 8 h | ||||
| Preoperative TACE | 1.254 (1.049–1.498) | 0.013 | 1.127 (0.942–1.348) | 0.190 |
| Operation time | 1.269 (1.061–1.515) | 0.009 | 1.279 (1.069–1.529) | 0.007 |
| ≥ 6 h | ||||
| Tumor number | 1.502 (1.268–1.778) | < 0.001 | 1.190 (0.978–1.446) | 0.082 |
| Multiple | ||||
| Donor type | 1.166 (0.984–1.383) | 0.076 | 1.172 (0.989–1.390) | 0.067 |
| DCD | ||||
| Beyond Milan criteria | 2.766 (2.320–3.297) | < 0.001 | 1.986 (1.552–2.540) | < 0.001 |
OS, overall survival; HR, hazard ratio; CI, confidence interval; BMI, body mass index; MELD, model for end-stage liver disease; CHILD, Child-Pugh; HBV, hepatitis B virus; TACE, transcatheter arterial chemoembolization.