The expression and mechanisms of circRNAs in BC
| Name | Expression | Function | Mechanism | Reference |
|---|---|---|---|---|
| circ-ABCB10 | Up | Oncogene | miR-1271 | 60 |
| circDENND4C | Up | Oncogene | HIF1α | 61 |
| circGFRA1 | Up | Oncogene in TNBC | miR-34a/GFRA1 | 62 |
| hsa_circ_0001982 | Up | Oncogene | miR-143 | 58 |
| circRNA_BARD1 | Up | Oncogene | miR-3942-3p/BARD1 | 63 |
| hsa_circ_0011946 | Up | Oncogene | miR-26a/b-RFC3 | 64 |
| circMYO9B | Up | Oncogene | miR-4316/FOXP4 | 65 |
| circIRAK3 | Up | Metastasis | miR-3607/FOXC1 | 66 |
| hsa_circ_0008039 | Up | Oncogene | miR-432-5p/E2F3 | 67 |
| circANKS1B | Up | Metastasis | miR-148a-3p/152-3p-USF1 | 68 |
| hsa_circ_0007534 | Up | Oncogene | miR-593/MUC19 | 69 |
| ciRS-7 | Up | Oncogene in TNBC | miR-1299/MMPs | 70 |
| circRNA‑MTO1 | Up | Monastrol resistance | TRAF4/Eg5 | 71 |
| circ-DNMT1 | Up | Oncogene | Activation of autophagy | 72 |
| circEPSTI1 | Up | Oncogene in TNBC | miR-4753/6809-BCL11A | 73 |
| FECR1 | Up | Metastasis | TET1 and DNMT1 | 74 |
| circ-UBAP2 | Up | Oncogene in TNBC | miR-661/MTA1 | 75 |
| circZNF609 | Up | Oncogene | miR-145-5p/p70S6K1 | 76 |
| hsa_circ_0072995 | Up | Oncogene | miR-30c-2-3p | 77 |
| hsa_circ_0052112 | Up | Oncogene | miR-125a-5p | 78 |
| hsa_circ_0006528 | Up | Oncogene and adriamycin resistance | miR-7-5p/MAPK/ERK pathway | 79 |
| hsa_circ_001569 | Up | Oncogene | PI3K-AKT pathway | 80 |
| circAGFG1 | Up | Oncogene in TNBC | miR-195-5p/CCNE1 | 81 |
| hsa_circ_001783 | Up | Oncogene | miR-200c-3p | 82 |
| circKIF4A | Up | Oncogene in TNBC | miR-375/KIF4A | 83 |
| CDR1as | Up | 5-fluorouracil resistance | miR-7/CCNE1 | 84 |
| circ_0103552 | Up | Oncogene | miR-1236 | 85 |
| hsa_circ_0136666 | Up | Oncogene | miR-1299/CDK6 | 86 |
| circRNA‑CER | Up | Oncogene | miR‑136/MMP13 | 87 |
| hsa_circ_0004771 | Up | Oncogene | miR-653/ZEB2 | 88 |
| circRNA_069718 | Up | Oncogene in TNBC | Wnt/β-catenin pathway | 89 |
| circANKRD12 | Up | Oncogene | Cell cycle | 90 |
| circRNA_100876 | Up | Oncogene | miR-361-3p | 91 |
| circPLK1 | Up | Oncogene in TNBC | miR-296-5p/PLK1 | 92 |
| circ-UBE2D2 | Up | Oncogene | miR-1236/1287 | 93 |
| hsa_circ_21439 | Up | Metastases | ceRNA | 94 |
| circAMOTL1 | Up | PTX resistance | AKT pathway | 95 |
| circDENND4C | Up | Oncogene | miR-200b/200c | 96 |
| circ_0067934 | Up | Oncogene | Mcl-1 | 97 |
| circ-TFCP2L1 | Up | Oncogene in TNBC | miR-7/PAK1 | 98 |
| circFBXL5 | Up | Oncogene | miR-660/SRSF6 | 99 |
| circ_0001667 | Up | Oncogene | miR-125a-5p/TAZ | 100 |
| circACAP2 | Up | Oncogene | miR-29a/b-3p-COL5A1 | 101 |
| circVAPA | Up | Metastases | miR-130a-5p | 102 |
| hsa_circ_002178 | Up | Oncogene | miR-328-3p/COL1A1 | 103 |
| circ-TFF1 | Up | Oncogene | miR-326/TFF1 | 104 |
| circ_0007255 | Up | Oncogene | miR-335-5p/SIX2 | 105 |
| hsa_circ_0008039 | Up | Oncogene | miR-515-5p/CBX4 | 106 |
| circRNF20 | Up | Oncogene | miR-487a/HIF-1α/HK2 | 107 |
| hsa_circ_0091074 | Up | Oncogene in TNBC | miR‑1297/TAZ/TEAD4 | 108 |
| circSKA3 | Up | Oncogene | Complex with Tks5 and integrin β1 | 109 |
| circCDYL | Up | Oncogene | miR-1275-ATG7/ULK1 | 110 |
| circ_103809 | Up | Oncogene | PI3K/AKT | 111 |
| circABCB10 | Up | Oncogene and PTX resistance | let-7a-5p/DUSP7 | 112 |
| circABCB10 | Up | Oncogene and radioresistance | miR-223-3p/PFN2 | 113 |
| circGNB1 | Up | Oncogene in TNBC | miR-141-5p/IGF1R | 114 |
| circSEPT9 | Up | Oncogene in TNBC | miR-637/LIF | 115 |
| circHMCU | Up | Oncogene | let-7 family | 116 |
| circKIF4A | Up | Oncogene | miR-152/ZEB1 | 117 |
| circRAD18 | Up | Oncogene | miR-613/HK2 | 118 |
| circRAD18 | Up | Oncogene in TNBC | miR-208a/3164-IGF1/FGF2 | 119 |
| circ-RNF111 | Up | PTX resistance | miR-140-5p/E2F3 | 120 |
| hsa_circ_0000515 | Up | Oncogene | miRNA-296-5p/CXCL10 | 121 |
| hsa_circ_0131242 | Up | Oncogene in TNBC | hsa-miR-2682 | 122 |
| circIFI30 | Up | Oncogene in TNBC | miR-520b-3p/CD44 | 123 |
| circ_DCAF6 | Up | Oncogene | miR-616-3p/GLI1/hedgehog pathway | 124 |
| circEIF3M | Up | Oncogene in TNBC | miR-33a/cyclin D1 | 125 |
| circ-ZEB1 | Up | Oncogene in TNBC | miR-448/eEF2 K | 126 |
| hsa_circRPPH1_015 | Up | Oncogene | miRNA-326/ELK1 | 127 |
| circMMP11 | Up | Oncogene | miR-1204/MMP11 | 128 |
| circ-Foxo3 | Down | TS | p53 and MDM2 | 49 |
| circRNA-000911 | Down | TS | miR‑449a | 129 |
| circ-Ccnb1 | Down | TS | p53 mutation | 130 |
| circ-ITCH | Down | TS in TNBC | miR-214/17-Wnt/β-catenin pathway | 131 |
| circASS1 | Down | Inhibition of metastasis | miR-4443/ASS1 | 132 |
| hsa_circ_0072309 | Down | TS | miR-492 | 133 |
| circYap | Down | TS | Suppression of translation | 134 |
| circTADA2As | Down | TS in TNBC | miR-203a-3p/SOCS3 | 135 |
| circRNA_0025202 | Down | TS and tamoxifen resistance | miR-182-5p/FOXO3a | 136 |
| circBMPR2 | Down | TS and tamoxifen resistance | miR-553/USP4 | 137 |
| circFBXW7 | Down | TS in TNBC | miR-197-3p/FBXW7, and encoded 185-aa protein | 138 |
| circKDM4C | Down | TS and doxorubicin resistance | miR-548p/PBLD | 139 |
| circAHNAK1 | Down | TS in TNBC | miR-421/RASA1 | 140 |
| hsa_circ_0000376 | Down | TS | miR-1285-3p/SMURF1-BTRC-TP53 | 141 |
| hsa_circ_0068033 | Down | TS | miR-659 | 142 |
| circ-LARP4 | Down | Doxorubicin resistance | / | 143 |
| circSCYL2 | Down | Inhibition of metastasis | EMT | 144 |
| circEHMT1 | Down | TS | miR-1233-3p/KLF4/MMP2 | 145 |
| circNFIC | Down | TS | miR-658/UPK1A | 146 |
| circRNA_103809 | Down | TS | miR-532-3p | 147 |
| circ-1073 | Down | TS | Interaction with HuR | 148 |
| circDDX17 | Down | TS | miR-605/CDK1 and p21 | 149 |
TS, tumor suppressor; Up, upregulation; Down, downregulation; TNBC, triple-negative breast cancer.