Univariate and multivariate analysis of predictive factors of upstaging
| Characteristics | Cases of DCIS
(n = 290) | % | Cases of DCISM & IBC
(n = 314) | % | Univariate
P-value | Multivariate
OR (95% CI), P |
| Age (years) | 0.230 | |||||
| ≤ 50 | 141 | 48.62 | 168 | 53.50 | ||
| > 50 | 149 | 51.38 | 146 | 46.50 | ||
| BC family history | 0.229 | |||||
| No | 225 | 77.59 | 256 | 81.53 | ||
| Yes | 65 | 22.41 | 58 | 18.47 | ||
| BMI | 0.881 | |||||
| < 25 | 221 | 76.21 | 236 | 75.16 | ||
| ≥ 25 | 60 | 20.69 | 66 | 21.02 | ||
| Unknown | 9 | 3.10 | 12 | 3.82 | ||
| Discharge | 0.210 | |||||
| No | 255 | 87.93 | 265 | 84.39 | ||
| Yes | 35 | 12.07 | 49 | 15.61 | ||
| Tumor size on ultrasonography | 0.005 | |||||
| ≤ 2 cm | 127 | 43.79 | 102 | 32.48 | Ref | |
| > 2 cm | 139 | 47.93 | 192 | 61.15 | 1.558 (1.094-2.218), 0.014 | |
| Unknown | 24 | 8.28 | 20 | 6.37 | ||
| Calcification on mammography | 0.169 | |||||
| Yes | 163 | 56.21 | 200 | 63.69 | ||
| No | 41 | 14.14 | 38 | 12.10 | ||
| Unknown | 86 | 29.66 | 76 | 24.20 | ||
| BI-RADS | 0.009 | |||||
| 3 | 2 | 0.69 | 4 | 1.27 | 1.207 (0.211-6.912), 0.833 | |
| 4A | 13 | 4.48 | 14 | 4.46 | 0.568 (0.233-1.384), 0.213 | |
| 4B | 66 | 22.76 | 49 | 15.61 | 0.435 (0.259-0.733), 0.002 | |
| 4C | 142 | 48.97 | 133 | 42.36 | 0.502 (0.329-0.764), 0.001 | |
| 5 | 59 | 20.34 | 104 | 33.12 | Ref | |
| Unknown | 8 | 2.76 | 10 | 3.18 | ||
DCIS, ductal carcinoma in situ; DCISM, ductal carcinoma in situ with microinvasion; IBC, invasive breast cancer; OR, odd ratio; CI, confidence interval; BC, breast cancer.