Inconsistency among meta-analysis
| Gene/ PMID | Gene (variant) | Cancer type | Year | Comparison | Ethnicity | OR (95% CI) | Publication bias/ heterogeneity | I2(%) | No. of studies | Cases/ control | Number of test allele or genotype (calculated value according to MAF) | Maf |
| BIRC5-31G/C | ||||||||||||
| 21611748 | BIRC5 (rs9904341) | GC | 2012 | CC vs. GG | Diverse | 2.88 (0.55–15.00) | 0.525/Na | Na | 3 | 707 (363/344） | Na (0–275) | 0.3886b |
| 23405077 | BIRC5 (rs9904341) | GC | 2013 | CC vs. GG+GC | Diverse | 1.75 (1.07–2.86) | 0.948/0.053 | Naa | 4 | 1147 (583/564) | 293 | 0.4752 |
| 24077840 | BIRC5 (rs9904341) | GC | 2014 | CC vs. GG | Diverse | 2.21 (1.06–4.64) | 0.317/0.013 | 72.4 | 4 | 1275 (451/824) | Na (0–495) | 0.3886b |
| CDH1 | ||||||||||||
| 21214416 | CDH1 (rs16260) | GC | 2011 | AA+AC vs. CC | Diverse | 1.03 (0.86–1.22) | 0.114/0.005 | Naa | 15 | 6196 (2509/3687) | 2909 | 0.2719 |
| AA+AC vs. CC | Asian | 0.84 (0.72–0.99) | 0.114/0.185 | Naa | 7 | 2671 (1220/1451) | 1049 | 0.2191 | ||||
| AA+AC vs. CC | European | 1.26 (0.98–1.61) | 0.114/0.022 | Naa | 8 | 3525 (1289/2236) | 1860 | 0.3061 | ||||
| 21570316 | CDH1 (rs16260) | GC | 2011 | AA vs. AC+CC | Diverse | 1.50 (1.03–2.19) | 0.54/Na | Naa | 17 | 8337 (3511/4826) | 586 | 0.2582 |
| 21612411 | CDH1 (rs16260) | GC | 2011 | AA vs. AC+CC | Diverse | 1.16 (0.83–1.63) | 0.606/0.004 | Naa | 14 | 6421 (3723/2698) | 488 | 0.2732 |
| 24870781 | CDH1 (rs16260) | GC | 2014 | AA+AC vs. CC | Diverse | 1.11 (0.95–1.30) | No/0.026 | 48.3 | 13 | 6412 (2722/3690) | Na (1510–3021) | 0.2356b |
| 25599647 | CDH1 (rs16260) | GC | 2015 | AA vs. CC | Diverse | 1.19 (0.89–1.58) | 0.323/0.001 | 55 | 22 | 9679 (4218/9679) | 672 | 0.2545 |
| CDH1 | ||||||||||||
| 21570316 | CDH1 (+54 T>C) | GC | 2011 | CC vs. CT+TT | Diverse | 1.00 (0.75–1.34） | Na/Na | Naa | 5 | 2280 (996/1284) | 248 | 0.2667 |
| 24870781 | CDH1 +54 T>C | GC | 2014 | CC+CT vs. TT | Diverse | 0.57 (0.44–0.75) | No/0.097 | 57.1 | 3 | 1373 (643/730) | Na (434–868) | 0.1546b |
| DNMT3B | ||||||||||||
| 27356727 | DNMT3B (rs1569686) | GC | 2016 | G vs. T | Diverse | 0.75 (0.30–1.88) | >0.05/0.00 | 91 | 2 | 1928 (706/1222) | 356 | 0.0953 |
| 27789275 | DNMT3B (rs1569686) | GC | 2016 | Dominant | Asian | 0.74 (0.61–0.90) | Na/0.000 | 81 | 5 | 3014 (1225/1789) | Na (832–1664) | 0.2762b |
| 29332452 | DNMT3B (rs1569686) | GC | 2017 | T vs. G | Asian | 1.69 (1.36–2.10) | Na/0.48 | 0 | 3 | 1891 (769/1122) | 3342 | 0.8614 |
| EGF | ||||||||||||
| 20033794 | EGF G61A (rs4444903) | GC | 2010 | A vs. G | Asian | 0.80 (0.71–0.92) | 0.033/0.389 | Naa | 3 | 2359 (1019/1340) | 1370 | 0.3104 |
| 20207214 | EGF 61A>G (rs4444903) | GC | 2010 | Dominant | Asian | 1.40 (1.03–1.90) | 0.108/0.86 | 0 | 3 | 2359 (1019/1340) | 2159 | 0.6896 |
| 23403233 | EGF 61A>G (rs4444903) | GC | 2013 | G vs. A | Diverse | 1.16 (0.96–1.39) | 0.476/0.065 | 58.5 | 4 | 3505 (1181/3505) | 4401 | 0.5936 |
| 25729328 | EGF 61A>G (rs4444903) | GC | 2014 | Dominant | Diverse | 1.256 (1.025–1.539) | 0.738/0.468 | 0 | 6 | 4309 (1547/2762) | Na (1701–3402) | 0.3948b |
| Dominant | Asian | 1.473 (1.134–1.914) | 0.738/0.928 | 0 | 5 | 3115 (1340/1775) | Na (1230–2460) | 0.3948b | ||||
| Dominant | Caucasian | 0.98 (0.71–1.35) | Na | Na | Na | Na | Na | Na | ||||
| 26072068 | EGF 61A>G (rs4444903) | GC | 2015 | G vs. A | Diverse | 1.18 (1.00–1.39) | 0.106/0.009 | 66.61 | 7 | 5194 (1992/3202) | 6524 | 0.6071 |
| Asian | 1.23 (1.04–1.46) | 0.106/0.028 | 61.48 | 6 | 4048 (2494/2977) | 5471 | 0.6711 | |||||
| Caucasian | 0.91 (0.71–1.15) | Na | Na | Na | Na | Na | Na | |||||
| ERCC5 29072052 | ERCC5 (rs2296147) | GC | 2017 | C vs. T | Asian | 1.268 (1.049–1.532) | 0.355/<0.001 | 82.83 | 5 | 7589 (3699/3890) | 3205 | 0.2121 |
| 28416771 | ERCC5 (rs2296147) | GC | 2017 | C vs. T | Asian | 0.99 (0.91–1.07) | 0.129/0.197 | Naa | 5 | 7589 (3699/3890) | 3205 | 0.2121 |
| GSTM1 21167396 | GSTM1 (null/active) | GC | 2010 | null vs. active | Diverse | 1.26 (1.14–1.39) | Naa/<0.0001 | 53 | 49 | 20976 (7746/13230) | 10977 | 0.2536 |
| Asian | 1.38 (1.22–1.57) | Na | Na | Na | Na | Na | Na | |||||
| Caucasian | 1.08 (0.93–1.26) | Na | Na | Na | Na | Na | Na | |||||
| 28327825 | GSTM1 (null/ present) | GC | 2017 | null vs. present | Diverse | 0.788 (0.725–0.857) | Naa/<0.0001 | Naa | 70 | 28549 (11208/ 17341) | 13890 | 0.2519 |
| hOGG1 22294108 | hOGG1 (Ser326Cys) | GC | 2012 | Dominant | Diverse | 0.91 (0.81–1.03) | 0.005/0.24 | 22 | 11 | 6165 (2180/3985) | 3435 | 0.3536 |
| 22343785 | hOGG1 (Ser326Cys) | GC | 2012 | Recessive | Diverse | 1.31 (1.03–1.67) | 0.665/0.160 | Naa | 9 | 3624 (1180/2444) | 363 | 0.2885 |
| Asian | 1.43 (1.06–1.92) | Na | Na | Na | Na | Na | Na | |||||
| Caucasian | 1.10 (0.72–1.68) | Na | Na | Na | Na | Na | Na | |||||
| 28415729 | hOGG1 (Ser326Cys) | GC | 2017 | C vs. G | Diverse | 1.02 (0.92–1.12) | 0.344/0.046 | 40.6 | 15 | 10046 (4024/6022) | 12568 | 0.6283 |
| IL1B 21653279 | IL-1B (rs1143627) | GC | 2011 | Recessive | Diverse | 0.88 (0.80–0.97) | No/0.158 | 21.9 | 25 | 11211 (4392/6819) | Na (0–5296) | 0.4724b |
| 26805397 | IL-1B (rs1143627) | GC | 2016 | Dominant | Diverse | 1.02 (0.91–1.15) | 0.398/0.001 | 48.3 | 37 | 15088 (6108/8980) | Na (7134–14267) | 0.4724b |
| IL-4 23576103 | IL-4 (rs2243250) | GC | 2013 | T vs. C | Diverse | 1.00 (0.84–1.19) | 0.884/Naa | Naa | 8 | 4226 (1813/2413) | 3284 | 0.3174 |
| 24072495 | IL-4 (rs2243250) | GC | 2014 | T vs. C | Diverse | 0.94 (0.83–1.06) | No/0.49 | Naa | 7 | 4252 (2454/1798) | 3390 | 0.4780 |
| Asian | 1.07 (0.90–1.27) | Na | Na | Na | Na | Na | Na | |||||
| Caucasian | 0.83 (0.70–0.98) | No/0.93 | 0 | 3 | 2592 (1700/892) | 863 | 0.1889 | |||||
| 27143935 | IL-4 (rs2243250) | GC | 2016 | T vs. C | Diverse | 1.05 (0.95–1.17) | 0.57/0.51 | 0 | 11 | 5617 (2247/3370) | 5245 | 0.4470 |
| 28656227 | IL-4 (rs2243250) | GC | 2017 | T vs. C | Diverse | 1.15 (1.01–1.32) | No/0.28 | 21 | 7 | 3887 (1475/2412) | 2894 | 0.3178 |
| IL-8 19777350 | IL-8 (251T/A) | GC | 2010 | AA vs. TT | Diverse | 1.363 (1.199–1.527) | >0.1/<0.001 | Naa | 10 | 5700 (2195/3505) | 909 | 0.3247 |
| Asian | 1.593 (1.013–2.173) | Na | Na | Na | Na | Na | Na | |||||
| 20363644 | IL-8 (251A/T) | GC | 2010 | TT+TA vs. AA | Diverse | 0.88 (0.69–1.12) | 0.23/<0.01 | Naa | 12 | 6905 (3012/3893) | 5832 | 0.6115 |
| 21681427 | IL-8 (251T/A) | GC | 2012 | AA+TA vs. TT | Diverse | 1.17 (1.01–1.36) | >0.05/<0.0001 | 65 | 18 | 10722 (4274/6498) | 6957 | 0.4025 |
| Asian | 1.27 (1.08–1.48) | >0.05/<0.0001 | 53 | 13 | 6860 (3036/3824) | 4190 | 0.3597 | |||||
| 22279522 | IL-8 (251A/T) | GC | 2012 | AA vs. TT | Diverse | 1.32 (1.05–1.66) | 0.031/0.000 | 66.7 | 18 | 10717 (4163/6554) | 1813 | 0.4049 |
| Asian | 1.52 (1.16–2.00) | 0.031/0.001 | 63.9 | 13 | 7033 (3153/3880) | 1036 | 0.3643 | |||||
| 26885219 | IL-8 (251A/T) | GC | 2015 | A vs. T | Diverse | 1.16 (1.05–1.27) | >0.05/<0.00000 1 | 66 | 26 | 13286 (5286/8000) | 10933 | 0.4038 |
| Asian | 1.23 (1.10–1.37) | >0.05/0.0005 | 61 | 17 | 8585 (3818/4767) | 6620 | 0.3651 | |||||
| IL-10 20087693 | IL-10 (-592C>A) | GC | 2011 | CC+CA vs. AA | Diverse | 1.16 (0.92–1.46) | 0.63/Naa | Naa | 12 | 6521 (2285/4236) | 5302 | 0.6289 |
| Asian | 1.31 (1.08–1.59) | 0.63/Naa | Naa | 5 | 2100 (864/1236) | 1303 | 0.4134 | |||||
| Caucasian | 0.93 (0.56–1.55) | Na | Na | Na | Na | Na | Na | |||||
| 22859944 | IL-10 (-592A/C) | GC | 2012 | Recessive | Diverse | 0.88 (0.74–1.05) | 0.914/0.020 | 46 | 17 | 8729 (2999/5730) | 2108 | 0.4333 |
| Asian | 0.81 (0.68–0.97) | 0.914/0.163 | 31.8 | 9 | 4008 (1526/2482) | 1652 | 0.6364 | |||||
| Caucasian | 1.03 (0.64–1.65) | Na | Na | Na | Na | Na | Na | |||||
| IL-10 23311038 | IL-10 (1082G>A) | GC | 2012 | A vs. G | Diverse | 0.489 (0.335–0.713) | 0.961/0.000 | 94.9 | 22 | 10254 (4289/5965) | 15860 | 0.7609 |
| Asian | 0.651 (0.506–0.838) | Na | Na | Na | Na | Na | Na | |||||
| Caucasian | 0.365 (0.140–0.949) | Na | Na | Na | Na | Na | Na | |||||
| 22335769 | IL-10 (1082A/G) | GC | 2012 | Dominant | Diverse | 1.41 (1.13–1.76) | 0.249/0.000 | 72.9 | 20 | 10062 (3631/6431) | 4278 | 0.2862 |
| Asian | 1.81 (1.44–2.27) | Na | Na | Na | Na | Na | Na | |||||
| Caucasian | 1.01 (0.77–1.33) | Na | Na | Na | Na | Na | Na | |||||
| IL-17F 24913709 | IL-17F (rs763780) | GC | 2014 | C vs. T | Asian | 1.29 (1.13–1.47) | 0.018/0.320 | 12.3 | 3 | 3360 (1500/1860) | 1084 | 0.1371 |
| 24965422 | IL-17F (rs763780) | GC | 2014 | C vs. T | Asian | 1.29 (1.14–1.46) | 0.102/Na | 0 | 4 | 4122 (1760/2362) | 1269 | 0.1319 |
| 25338988 | IL-17F (rs763780) | GC | 2014 | Dominant | Asian | 1.30 (1.12–1.50) | Naa/0.4 | 0 | 4 | 4122 (1760/2362) | 1269 | 0.1319 |
| 25500254 | IL-17F (rs763780) | GC | 2015 | C vs. T | Asian | 1.30 (1.15–1.47) | 0.860/0.528 | 0 | 5 | 4376 (1784/2592) | Na (818) | 0.0935b |
| 26770352 | IL-17F (rs763780) | GC | 2015 | C vs. T | Asian | 1.08 (0.81–1.44) | 0.83/Naa | 86.3 | 8 | 6693 (2917/3776) | 4944 | 0.337 |
| 26843459 | IL-17F (rs763780) | GC | 2016 | C vs. T | Asian | 1.37 (1.25–1.51) | No/0.17 | 31 | 9 | 7346 (3244/4102) | 2187 | 0.1273 |
| miR-146a 21947843 | miR-146a (rs2910164) | GC | 2012 | Dominant | Asian | 1.15 (0.88–1.50) | No/0.325 | 73 | 3 | 4077 (1439/2638) | 2498 | 0.3945 |
| 24528016 | miR-146a (rs2910164) | GC | 2014 | C vs. G | Asian | 0.87 (0.81–0.93) | No/Naa | 47.6 | 4 | 6346 (3003/3343) | 6543 | 0.5316 |
| 25326754 | miR-146a (rs2910164) | GC | 2014 | C vs. G | Diverse | 1.028 (0.914–1.155) | 0.355/0.000 | 72.5 | 9 | 11243 (4507/6736) | 10440 | 0.4463 |
| 25983750 | miR-146a (rs2910164) | GC | 2015 | Dominant | Diverse | 0.88 (0.80–0.97) | 0.481/0.12 | 36 | 9 | 11312 (4468/6844) | 8695 | 0.5595 |
| 26337564 | miR-146a (rs2910164) | GC | 2015 | C vs. G | Diverse | 0.975 (0.874–1.088) | No/0.001 | 69 | 10 | 11864 (5020/6844) | 12902 | 0.5595 |
| 29127520 | miR-146a (rs2910164) | GC | 2017 | C vs. G | Diverse | 0.984 (0.903–1.072) | >0.05/0.005 | 57.3 | 13 | 12773 (5831/6942) | 14129 | 0.5632 |
| miR-196a2 23160898 | miR-196a2 (rs11614913) | GC | 2013 | CC vs. TT | Asian | 2.19 (1.23–3.91) | Na/0.07 | 68.5 | 2 | 1709 (782/927) | Na (568–1137) | 0.3327 |
| 25983750 | miR-196a2 (rs11614913) | GC | 2015 | C vs. T | Diverse | 1.25 (0.97–1.60) | present/Naa | Naa | 9 | 9410 (3992/5418) | 9305 | 0.4862 |
| MMP2 23644699 | MMP2 (rs243865) | GC | 2013 | Dominant | Diverse | 0.68 (0.47–0.99) | 0.072/<0.00001 | 84 | 8 | 5154 (1792/3353) | 1298 | 0.1506 |
| 24606450 | MMP2 (rs243865) | GC | 2014 | T vs. C | Diverse | 1.042 (0.496–2.186) | Naa/0.107 | 40.7 | 8 | 5770 (1926/3844) | 1468 | 0.1316 |
| MMP7 23644699 | MMP7 (rs11568818) | GC | 2013 | Dominant | Diverse | 1.49 (1.17–1.91) | 0.368/0.6 | 0 | 5 | 1999 (757/1242) | 547 | 0.1369 |
| 23893803 | MMP7 (rs11568818) | GC | 2013 | A vs. G | Diverse | 0.91 (0.78–1.06) | Na/0.006 | 76 | 4 | 1891 (686/1205) | 371 | 0.1025 |
| 24606450 | MMP7 (rs11568818) | GC | 2014 | Recessive | Diverse | 1.768 (1.153–2.712) | Naa/0.54 | 0 | 5 | 2175 (701/1474) | 606 | 0.1547 |
| 23725125 | MMP7 (rs11568818) | GC | 2013 | Recessive | Diverse | 1.13 (1.01–1.26) | Na/0.711 | Na | 6 | 2893 (1039/1854) | Na (1036–2072) | 0.3582b |
| MMP1 23893803 | MMP1 (rs1799750) | GC | 2013 | 2G vs. 1G | Asian | 1.03 (0.94–1.12) | Na/0.118 | 53.2 | 3 | 1412 (644/768) | 2070 | 0.7356 |
| 24606450 | MMP1 (rs1799750) | GC | 2014 | 2G vs. 1G | Asian | 0.927 (0.480–1.791) | Naa/0.134 | 55.5 | 2 | 914 (398/516) | 533 | 0.2926 |
| 26392779 | MMP1 (rs1799750) | GC | 2015 | 2G vs. 1G | Asian | 1.05 (1.01–1.06) | 0.964/0.101 | 45.7 | 6 | 2920 (1377/1543) | 3952 | 0.664 |
| MMP9 24606450 | MMP9 (-1562C>T) | GC | 2014 | T vs. C | Diverse | 1.615 (0.872–2.991) | Naa/0.847 | 0 | 4 | 2116 (636/1480) | 693 | 0.1632 |
| 29228747 | MMP9 (-1562C>T) | GC | 2017 | C vs. T | Diverse | 1.150 (1.014–1.304) | >0.1/0.231 | 23.9 | 9 | 3555 (1345/2210) | Na (1102) | 0.1552b |
| TGF-β1 24254308 | TGF-β1 (rs1800469) | GC | 2014 | Recessive | Diverse | 1.23 (1.09–1.38) | No/0.13 | 35.7 | 10 | 6522 (2990/3532) | 1623 | 0.4561 |
| 26770387 | TGF-β1 (rs1800469) | GC | 2015 | T vs. C | Diverse | 0.95 (0.86–1.03) | No/<0.01 | 82 | 31 | 28474 (12940/ 15530) | 22729 | 0.4097 |
| TGF-β1 24254308 | TGF-β1 (rs1800470) | GC | 2014 | C vs. T | Diverse | 1.11 (0.90–1.35） | No/Naa | Naa | 6 | 4884 (2260/2624) | 4676 | 0.4703 |
| 26770387 | TGF-β1 (rs1800470) | GC | 2015 | C vs. T | Diverse | 1.38 (1.11–1.73) | No/<0.01 | 87 | 11 | 5703 (2730/2973) | 5435 | 0.4601 |
| TNF-α 22748850 | TNF-α (rs909253) | GC | 2012 | Dominant | Diverse | 1.11 (0.93–1.36) | Naa/0.001 | Naa | 16 | 8189 (2758/5341) | 6498 | 0.5831 |
| 23900678 | TNF-α (rs361525) | GC | 2013 | A vs. G | Diverse | 1.32 (1.02–1.72) | No/0.002 | 59.2 | 15 | 7795 (Na/Na） | Na (949) | 0.0609b |
Na: Not available, No: significant publication bias/heterogeneity was not found, Diverse: two or more ethnicities were reported in the meta-analysis.aThe information is calculated according to the data provided in the article since the article did not present (such as I2, OR, publication bias and heterogeneity)bThe MAF is obtained from dbSNP database