Association of ≥20 years of smoking, obesity, VDR-BsmI genotype, and VDR-FokI genotype as single or combined with variables of melanoma.

Single or combined variable	Adjusted¹ OR (CI), P (All melanoma cases vs. healthy controls)	Adjusted² OR (CI), P (Melanomas vs. healthy controls)	Adjusted¹ OR (CI), P (MetM vs. healthy controls)	Adjusted² OR (CI), P (MetM vs. healthy controls)	Adjusted¹ OR (CI), P (NMetM vs. healthy controls)	Adjusted² OR (CI), P (NMetM vs. healthy controls)
≥20 years of ever-smoking	2.19 (1.13–4.24), 0.020	1.79 (0.85–3.74), 0.124	3.16 (1.44–6.95), 0.004	2.46 (1.00–6.05), 0.050	1.50 (0.69–3.28), 0.304	1.13 (0.47–2.73), 0.789
BMI >30 kg/m²	3.20 (1.12–9.14), 0.030	5.28 (1.73–16.1), 0.003	3.95 (1.22–12.8), 0.022	7.74 (2.02–29.6), 0.003	2.51 (0.76–8.33), 0.132	3.69 (1.04–13.1), 0.043
BB	0.92 (0.51–1.66), 0.777	0.99 (0.52–1.91), 0.982	0.76 (0.34–1.68), 0.495	0.93 (0.39–2.25), 0.881	1.06 (0.54–2.08), 0.874	1.01 (0.48–2.12), 0.975
Bb	1.47 (0.87–2.49), 0.147	1.48 (0.83–2.63), 0.186	1.09 (0.56–2.12), 0.808	0.89 (0.41–1.92), 0.768	1.88 (1.01–3.49), 0.045	2.15 (1.09–4.25), 0.028
bb	0.66 (0.36–1.20), 0.171	0.61 (0.31–1.18), 0.140	1.15 (0.56–2.35), 0.705	1.21 (0.53–2.77), 0.644	0.36 (0.16–0.81), 0.013	0.30 (0.12–0.75), 0.010
BB+Bb (B allele)	1.52 (0.83–2.76), 0.171	1.65 (0.85–3.19), 0.140	0.87 (0.42–1.78), 0.705	0.82 (0.36–1.88), 0.644	2.81 (1.24–6.36), 0.013	3.30 (1.34–8.15), 0.010
Bb+bb (b allele)	1.09 (0.60–1.97), 0.777	1.01 (0.52–1.94), 0.982	1.32 (0.60–2.92), 0.495	1.07 (0.44–2.58), 0.881	0.95 (0.48–1.86), 0.874	0.99 (0.47–2.08), 0.975
bb plus ≥20 years of smoking	4.16 (0.86–20.2), 0.077^	3.24 (0.58–17.9), 0.179	6.81 (1.27–36.6), 0.025	6.99 (1.08–45.2), 0.041	1.68 (0.23–12.4), 0.612	0.98 (0.10–9.54), 0.987
Bb+bb plus ≥20 years of smoking	2.08 (1.00–4.29), 0.049	1.75 (0.78–3.92), 0.171	3.29 (1.42–7.60), 0.005	2.42 (0.93–6.28), 0.070^	1.19 (0.49–2.89), 0.702	0.94 (0.36–2.51), 0.910
bb plus BMI >30 kg/m²	–^a	–^a	–^a	–^a	–^a	–^a
Bb+bb plus BMI >30 kg/m²	3.20 (1.00–10.3), 0.050	4.35 (1.28–14.8), 0.018	4.34 (1.22–15.5), 0.024	6.55 (1.60–26.9), 0.009	2.26 (0.58–8.85), 0.242	2.81 (0.67–11.8), 0.158
Bb+bb plus ≥20 years of smoking, and plus BMI >30 kg/m²	8.61 (1.06–69.8), 0.044	12.0 (1.40–104), 0.024	17.4 (2.07–146), 0.008	22.7 (2.46–209), 0.006	1.93 (0.12–32.1), 0.646	2.68 (0.14–49.8), 0.508
FF	0.80 (0.47–1.36), 0.413	0.90 (0.50–1.62), 0.732	0.59 (0.29–1.20), 0.145	0.60 (0.27–1.33), 0.206	0.97 (0.53–1.80), 0.935	1.12 (0.57–2.19), 0.749
Ff	1.30 (0.77–2.20), 0.317	1.21 (0.68–2.17), 0.516	1.70 (0.87–3.35), 0.122	1.59 (0.73–3.45), 0.243	1.11 (0.60–2.05), 0.728	1.03 (0.53–2.03), 0.923
ff	0.88 (0.39–1.98), 0.758	0.81 (0.33–1.96), 0.638	0.90 (0.32–2.54), 0.846	1.08 (0.34–3.41), 0.902	0.82 (0.31–2.14), 0.682	0.72 (0.25–2.03), 0.531
FF+Ff (F allele)	1.13 (0.51–2.55), 0.758	1.24 (0.51–3.01), 0.638	1.11 (0.39–3.12), 0.846	0.93 (0.29–2.95), 0.902	1.22 (0.47–3.21), 0.682	1.39 (0.49–3.96), 0.531
Ff+ff (f allele)	1.25 (0.73–2.12), 0.413	1.11 (0.62–1.99), 0.732	1.69 (0.83–3.43), 0.145	1.68 (0.75–3.74), 0.206	1.03 (0.55–1.89), 0.935	0.90 (0.46–1.75), 0.749
Ff plus ≥20 years of smoking	2.77 (1.10–6.98), 0.031	2.36 (0.84–6.58), 0.102	4.02 (1.45–11.1), 0.007	3.69 (1.12–12.2), 0.032	1.78 (0.59–5.39), 0.307	1.48 (0.42–5.23), 0.545
Ff+ff plus ≥20 years of smoking	2.86 (1.24–6.60), 0.013	2.30 (0.91–5.82), 0.080^	4.21 (1.65–10.7), 0.003	3.92 (1.31–11.7), 0.014	1.83 (0.68–4.93), 0.234	1.31 (0.42–4.11), 0.646
Ff plus BMI >30 kg/m²	4.41 (0.92–21.1), 0.063^	6.91 (1.35–35.4), 0.020	6.09 (1.11–33.4), 0.037	14.6 (2.16–98.3), 0.006	3.61 (0.63–20.5), 0.148	4.39 (0.71–27.2), 0.112
Ff+ff plus BMI >30 kg/m²	6.09 (1.32–28.0), 0.020	8.89 (1.82–43.4), 0.007	8.50 (1.66–43.4), 0.010	17.8 (2.82–112), 0.002	4.53 (0.85–24.3), 0.078^	5.63 (0.98–32.4), 0.053^

¹Adjusted OR (CI) for gender, and age. ²Adjusted OR for gender, age, phototype 1+2, total body nevi >50, and >10 lifelong sunburns. ^aOR uncountable because one of the compared group had zero subject. Significant differences were indicated in bold, tendencies were evidenced with superscript ^.