Distribution of cases and controls with regard to the ALDH2 genotype, n (%)
| Case | Control | Crude OR (95%CI) | P† | Adjusted OR (95%CI) | P‡ | ||||
| ALDH2*2/*2+*1/*2 | ALDH2*1/*1 | ALDH2*2/*2+*1/*2 | ALDH2*1/*1 | ||||||
| Total | 691 (25.7) | 1995 (74.3) | 1012 (27.5) | 2663 (72.5) | 0.91 (0.81–1.02) | 0.107 | 1.07 (0.95–1.22) | 0.271 | |
| Gender | |||||||||
| Male | 519 (24.9) | 1562 (75.1) | 517 (27.7) | 1349 (72.3) | 0.87 (0.75–1.00) | 0.049 | 1.16 (0.99–1.35) | 0.061 | |
| Female | 172 (28.4) | 433 (71.6) | 495 (27.4) | 1314 (72.6) | 1.05 (0.86–1.29) | 0.612 | 0.92 (0.74–1.15) | 0.468 | |
| Age, years | |||||||||
| ≤60 | 331 (25.2) | 983 (74.8) | 867 (27.7) | 2267 (72.3) | 0.88 (0.76–1.02) | 0.090 | 1.10 (0.95–1.29) | 0.202 | |
| >60 | 360 (26.2) | 1012 (73.8) | 145 (26.8) | 396 (73.2) | 0.97 (0.78–1.22) | 0.801 | 1.00 (0.79–1.26) | 0.978 | |
| Area | |||||||||
| HIA | 337 (23.7) | 1083 (76.3) | 453 (25.2) | 1346 (74.8) | 0.92 (0.79–1.09) | 0.343 | 1.10 (0.93–1.32) | 0.275 | |
| LIA | 354 (28.0) | 912 (72.0) | 559 (29.8) | 1317 (70.2) | 0.91 (0.78–1.07) | 0.266 | 1.04 (0.87–1.25) | 0.658 | |
† P: for variables was calculated using Chi-squared test.
‡ P: for variables was calculated using binary logistic regression after adjusting for covariates, including gender, age and area.
ALDH2: acetaldehyde dehydrogenase-2; HIA: high-incidence area; LIA: low-incidence area.