Table 3.

Appraisement of the diagnostic criteria detected in the pleural effusions.

Group	Markers	Sensitivity (%)	Specificity (%)	Diagnostic accordance rate (%)	Youden Index
1	hTERT mRNA	81.8^{^a}	90.5^{^c}	86.1^{^b}	0.723
2	CEA	52.3^{^b}	92.9^{^c}	72.1^{^b}	0.452
3	CA19-9	34.1^{^a}	90.5^{^c}	61.6^{^a}	0.246
4	hTERTmRNA + CEA	97.7	83.3	90.7	0.81
5	hTERTmRNA + CA19-9	95.5	81.0	88.4	0.765
6	hTERTmRNA + CEA + CA19-9	97.7	78.6	88.4	0.763
7	CEA + CA19-9	59.1	88.1	73.3	0.472

↵a refers to the ratio from a comparison between the tumor marker and the group of combined markers, P < 0.05;
↵b refers to the comparison between the marker and the groups of combined markers, except the Group 7, χ² ≥ 21.25, P < 0.0001;
↵c indicates the comparison between the marker and all groups of combined markers, Fisher’s exact probability and two-sided test, P >0.05.