PT  - JOURNAL ARTICLE
AU  - Mehrdad Asghari Estiar
AU  - Parvin Mehdipour
TI  - ATM in breast and brain tumors: a comprehensive review
AID  - 10.20892/j.issn.2095-3941.2018.0022
DP  - 2018 Aug 01
TA  - Cancer Biology and Medicine
PG  - 210--227
VI  - 15
IP  - 3
4099  - http://www.cancerbiomed.org/content/15/3/210.short
4100  - http://www.cancerbiomed.org/content/15/3/210.full
SO  - Cancer Biol Med2018 Aug 01; 15
AB  - The ATM gene is mutated in the syndrome, ataxia-telangiectasia (AT), which is characterized by predisposition to cancer. Patients with AT have an elevated risk of breast and brain tumors Carrying mutations in ATM, patients with AT have an elevated risk of breast and brain tumors. An increased frequency of ATM mutations has also been reported in patients with breast and brain tumors; however, the magnitude of this risk remains uncertain. With the exception of a few common mutations, the spectrum of ATM alterations is heterogeneous in diverse populations, and appears to be remarkably dependent on the ethnicity of patients. This review aims to provide an easily accessible summary of common variants in different populations which could be useful in ATM screening programs. In addition, we have summarized previous research on ATM, including its molecular functions. We attempt to demonstrate the significance of ATM in exploration of breast and brain tumors and its potential as a therapeutic target.