RT Journal Article
SR Electronic
T1 Quantum Dots for Cancer Research: Current Status, Remaining Issues, and Future Perspectives
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 151
OP 163
DO 10.7497/j.issn.2095-3941.2012.03.001
VO 9
IS 3
A1 Min Fang
A1 Chun-wei Peng
A1 Dai-Wen Pang
A1 Yan Li
YR 2012
UL http://www.cancerbiomed.org/content/9/3/151.abstract
AB Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide. The mechanisms of carcinogenesis, cancer invasion, and metastasis remain unclear. Thus, the development of a novel approach for cancer detection is urgent, and real-time monitoring is crucial in revealing its underlying biological mechanisms. With the optical and chemical advantages of quantum dots (QDs), QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study. This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro, as well as the remaining issues and future perspectives.