RT Journal Article
SR Electronic
T1 Radiotherapy in combination with systemic therapies for brain metastases: current status and progress
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 910
OP 922
DO 10.20892/j.issn.2095-3941.2020.0109
VO 17
IS 4
A1 Lei Liu
A1 Wanqi Chen
A1 Ruopeng Zhang
A1 Yuekun Wang
A1 Penghao Liu
A1 Xin Lian
A1 Fuquan Zhang
A1 Yu Wang
A1 Wenbin Ma
YR 2020
UL http://www.cancerbiomed.org/content/17/4/910.abstract
AB Brain metastases (BMs) are the most common cause of intracranial neoplasms in adults with poor prognosis. Most BMs originate from lung cancer, breast cancer, or melanoma. Radiotherapy (RT), including whole brain radiotherapy (WBRT) and stereotactic radiation surgery (SRS), has been widely explored and is considered a mainstay anticancer treatment for BMs. Over the past decade, the advent of novel systemic therapies has revolutionized the treatment of BMs. In this context, there is a strong rationale for using a combination of treatments based on RT, with the aim of achieving both local disease control and extracranial disease control. This review focuses on describing the latest progress in RT as well as the synergistic effects of the optimal combinations of RT and systemic treatment modalities for BMs, to provide perspectives on current treatments.