PT  - JOURNAL ARTICLE
AU  - Lei Liu
AU  - Wanqi Chen
AU  - Ruopeng Zhang
AU  - Yuekun Wang
AU  - Penghao Liu
AU  - Xin Lian
AU  - Fuquan Zhang
AU  - Yu Wang
AU  - Wenbin Ma
TI  - Radiotherapy in combination with systemic therapies for brain metastases: current status and progress
AID  - 10.20892/j.issn.2095-3941.2020.0109
DP  - 2020 Nov 15
TA  - Cancer Biology and Medicine
PG  - 910--922
VI  - 17
IP  - 4
4099  - http://www.cancerbiomed.org/content/17/4/910.short
4100  - http://www.cancerbiomed.org/content/17/4/910.full
SO  - Cancer Biol Med2020 Nov 15; 17
AB  - Brain metastases (BMs) are the most common cause of intracranial neoplasms in adults with poor prognosis. Most BMs originate from lung cancer, breast cancer, or melanoma. Radiotherapy (RT), including whole brain radiotherapy (WBRT) and stereotactic radiation surgery (SRS), has been widely explored and is considered a mainstay anticancer treatment for BMs. Over the past decade, the advent of novel systemic therapies has revolutionized the treatment of BMs. In this context, there is a strong rationale for using a combination of treatments based on RT, with the aim of achieving both local disease control and extracranial disease control. This review focuses on describing the latest progress in RT as well as the synergistic effects of the optimal combinations of RT and systemic treatment modalities for BMs, to provide perspectives on current treatments.