PT  - JOURNAL ARTICLE
AU  - Hu, Jiali
AU  - Li, Ke
AU  - Li, Zhanghuan
AU  - Gao, Chao
AU  - Guo, Fei
AU  - Wang, Yingmei
AU  - Xue, Fengxia
TI  - <em>Sex-determining region Y box-containing</em> genes: regulators and biomarkers in gynecological cancers
AID  - 10.20892/j.issn.2095-3941.2019.0062
DP  - 2019 Aug 01
TA  - Cancer Biology and Medicine
PG  - 462--474
VI  - 16
IP  - 3
4099  - http://www.cancerbiomed.org/content/16/3/462.short
4100  - http://www.cancerbiomed.org/content/16/3/462.full
SO  - Cancer Biol Med2019 Aug 01; 16
AB  - Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis. Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical, and endometrial cancer. In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels. Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers. An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers.